The big picture
Protein language models, unfolded

Attention is all you need to fold proteins.

For beginners in protein design, and for anyone who forgets the basics. This is the closest we have come to what nature does in seconds, and what nature does is still the better-kept secret. Start with the mechanism, then read the models that use it.

A map of machine intelligence

Select an idea to look inside
AIArtificial intelligence01MLMachine learningtrees · regression · kernelsDLDeep learningCNNs · RNNs · and moreTransformersThe architectureText language modelsBERT · decoder LLMsProtein language modelsESM-2 · ProtT5 · ProtBERT

One family of architectures. More than one language.

FieldsArchitectureApplications
01 to 06 / Select to discover

The model catalogue

Architectures, weights and sources

Your first discoveries

Start anywhere. Follow your curiosity.
01 / The intuition

In plain language

is the broad field. is an approach within it: learning patterns from data rather than specifying every rule.

02 / Under the hood

The technical idea

is a subset of based on multilayer neural networks. are one architecture; language modeling is an objective. These are related categories, not synonyms.

03 / The biology connection

From data to proteins

apply sequence-learning objectives to . Not every protein model predicts a 3D structure, and not every language model is a .

Look deeper: mathematics, methods & limitations

AI ⊃ ML ⊃ DL

Classical includes logistic regression, decision trees, random forests and support machines. “Classical” does not necessarily mean linear, simple or obsolete.

A () is a language model at large scale; there is no universal threshold. A (, sometimes called a ) models amino-acid sequences. Here always means , not simply pretrained language model.

Follow the numbered galleries for a guided visit, or select any in the map. Hover, click, touch and keyboard focus reveal the same information. All live experiments use compact educational models, not hosted foundation models.

Go to the original research

A moment to connect the dots

Which relationship is correct?

A guided visit, at your own pace.Next: Learning from data